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The Villans inflicted Rafa Benitez side's second defeat in just three Barclays Premier League matches with a 3-1 win at Anfield.
However, a win over Bolton will provide the perfect tonic ahead of the international break and Liverpool have completed the league double over Wanderers in each of the previous two seasons.
Last campaign, goals from Dirk Kuyt and Steven Gerrard helped the Reds to a comfortable 2-0 win at the Reebok.
In 2007-08, Fabio Aurelio scored his first goal for Liverpool in a fine 3-1 victory, with Gerrard and Ryan Babel also finding the back of the net for Benitez's charges.
The opposition
Bolton have endured a difficult opening to the season, although they will be hoping to build on Tuesday's Carling Cup victory over John Barnes' Tranmere Rovers at Prenton Park.
The Trotters have lost both of their Barclays Premier League fixtures so far this term and are yet to score a goal after going down 1-0 to Sunderland and Hull City.
Manager Gary Megson steered Wanderers to a 13th place finish in the table last season, and moved to bolster his defensive ranks over the course of the summer.
Bolton brought in Zat Knight from Aston Villa, while Portsmouth's Sean Davies and Hull full-back Sam Ricketts moved to the Reebok. The experienced Paul Robinson was also snapped-up on loan from West Brom.
The boss
Gary Megson took up the reins at Bolton in October 2007, replacing Liverpool's current assistant manager Sammy Lee in the Reebok Stadium hot seat.
Megson may only be 50 years of age, but he has taken charge of more than 500 matches for no less than eight clubs over the past 14 years.
He cut his managerial teeth at Norwich City in 1995, whilst also on the playing staff at Carrow Road.
Spells in charge at Blackpool, Stockport and Stoke followed before Megson took control of West Bromwich Albion, leading the Baggies into the Championship playoffs in his second season at the Hawthorns.
The following year, West Brom won promotion to the Premier League – an achievement that won Megson the title of Lord of the Manor of West Bromwich.
Their stay in the top-flight was short lived as they were relegated the following May but Megson masterminded an immediate return, only to leave the club in November 2004 after a poor start to the season.
Megson then moved to Nottingham Forest prior to taking up a coaching post at Stoke.
In September 2007, he was unveiled as Leicester manager. However, he lasted just 41 days and nine matches at the Walkers Stadium as Bolton came calling.
In his playing days, Megson was known as a tough tackling midfielder and he turned out for nine different clubs, including a short spell at Everton.
The danger man
Powerful front man Kevin Davies began the new campaign fresh from being named as Bolton's Player of the Year for the second successive season.
The Trotters' captain has established himself as a huge favourite with the Reebok Stadium faithful since joining the club on the free-transfer from Southampton in 2003.
Davies began his career at Chesterfield and he helped the Spireites into the semi-finals of the FA Cup in 1997, where they were narrowly beaten by Middlesbrough at Old Trafford.
A move to the Premier League beckoned and Davies joined Southampton, where he impressed during the 1997-98 season.
His efforts earned him a lucrative big-money move to Blackburn, although his time at Ewood Park was not as profitable as at previous clubs and he could only muster one league goal.
He returned to Southampton just a year later, prior to signing for Bolton when his contract expired at St Mary's.
The 32-year-old was awarded the Bolton captaincy earlier this year following Kevin Nolan's transfer to Newcastle United and Davies recently spoke of his desire to see out the remainder of his career at the Reebok.
"I hope that I can finish my career at Bolton," he said. "I am happy both on and off the pitch. It feels like home.
"I have two years left on my contract and unless the club want to sell me, I would be happy to stay here for the rest of my career."
The legend
Nat Lofthouse is arguably the greatest player to have ever donned the Bolton jersey.
The ultimate one-club man, the centre forward spent his entire career with the Trotters.
After signing for the Lancashire club as a 14-year-old amateur in 1939, he went on to make in excess of 500 appearances for Wanderers over a 21 year period, scoring 285 goals, although the outbreak of the Second World War delayed his league debut.
Lofthouse netted twice in Bolton's FA Cup final success over Manchester United in 1958 and though he was forced to retire due to an ankle injury soon after, he remains Bolton's all-time leading goalscorer.
He also won 33 caps for England and earned the nickname the 'Lion of Vienna' after netting a brace in a famous 3-2 victory against Austria in 1952.
The 83-year-old was an inaugural inductee to the English Football Hall of Fame 2002 and he is currently Bolton's life president.
Bolton Wanderers fact file
Bolton were originally formed by Reverend John Farrall Wright in 1874 as Christ Church FC. They changed their name three years later.
They were one of the founder members of the football league in 1888.
Their nickname 'The Trotters' stems from their early history when a piggery was stationed nearby one of their training pitches. It's said that players had to 'trot' through the pig-pens to retrieve balls that had been cleared.
Wanderers play at the Reebok Stadium, which was opened in 1997 and has a capacity of 28,723.
Burnden Park was their previous home for 102 years and hosted the 1901 FA Cup Final replay between Tottenham and Sheffield United.
Bolton won the first FA Cup Final to be played at Wembley in 1923, beating West Ham 2-0.
They've since lifted the trophy on three more occasions, with their last triumph coming in 1958 - which is also their last major honour.
Bolton contested the 1995 Coca-Cola Cup Final with Liverpool at Wembley as Steve McManaman inspired the Reds to a 2-1 victory.
Anfield legend Phil Neal managed the Trotters for seven years from 1985 to 1992, while current Reds' assistant Sammy Lee also had a short stint in charge at the Reebok in 2007-08.
Players to have turned out for both Liverpool and Bolton include Roger Hunt, Nicolas Anelka, Sammy Lee, El-Hadji Diouf, Roger Hunt, Danny Guthrie and Jason McAteer.
Match stats By Ged Rea
Last season Liverpool did the double over Bolton for a second successive season and for the 4th time in the Premiership. The Reds have never achieved the feat in three successive seasons.
Rafa Benitez suffered his first defeat as Reds boss on this ground in August 2004.
Liverpool have lost just three of the last 26 meetings between the sides home and away – all at Bolton.
Liverpool's biggest win at Bolton came in September 1907 when they won 4-0.
The last goalless draw in the League at Bolton came in December 1937. Bolton have lost two of their last nine league games at the Reebok - 3-1 to Fulham in March and 1-0 to Sunderland on the opening day of this campaign.
Bolton have scored in only one of their last six league games. They have not won in the last nine league games and only one of the last 13.
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